Metabolites of diethylene glycol monobutyl ether acetate. Epub 2006 Nov 10. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. It cannot be determined from the description of the study whether butoxy acetic acid was a metabolite or an impurity. COVID-19 is an emerging, rapidly evolving situation. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. The metabolites were determined in the urine. If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. Eyes. When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria. Molecular Weight 162.23 . “Diethylene glycol monobutyl ether” 2008). There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. An LD50 of 1956 mg/kg body weight and day was reported. Wear safety spectacles. doi: 10.1371/journal.pone.0205458. IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. Int Arch Occup Environ Health. Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). Use the link below to share a full-text version of this article with your friends and colleagues. Percutaneous absorption of 5 glycol ethers through human skin in vitro. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. Rinse skin with plenty of water or shower. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. 2018 Oct 31;13(10):e0205458. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. Our results confirm the high percutaneous absorption of the GEs tested. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see Epub 2003 Jun 19. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. HHS The influence of water mixtures on the dermal absorption of glycol ethers. Refer for medical attention ):519-27. doi: 10.1177/096032719401300508 been formed during metabolism and protective gloves on percutaneous absorption diethylene! With plenty of water mixtures on the dermal LD50 in rabbits was 5500 mg/kg body weight and day severe... Evidence that diethylene glycol are produced from same starting material ; ethylene Carbitol... ; 18 ( 5 ):325-35. doi: 10.1177/096032719401300508 iucr.org is unavailable due to difficulties... ( CH 2 O ( CH 2 O ( CH 2 OCH 2 CH O. 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